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, blood, interstitial fluid/edema, or cerebrospinal fluid [CSF]).
Small increases in volume can be accommodated by an outflow of CSF from the cranial cavity into the spinal canal, producing an exponential pressure-volume relation- ship (see Fig. 84.1).
Pressure gradients are initially hydraulically equilibrated, with CSF moving from the ventricular chambers to the extracranial spinal space.
Brain herniation may also contribute to imped- ance of CSF drainage either by occlusion of the foramina of Monro in the case of lateral herniation or by occlusion of the third ventricle and aqueduct by supratentorial hernia- tion through the tentorial gap.
, arterial, venous, CSF) or lung injury.31 However, in up to one-third of cases, the cause of the fever remains unexplained and often is classified as central fever.28
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